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Weak noise approximate inference for diffusion models

calendar icon Nov 6, 2007 3215 views
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The modelling of the Stochastic Kinetics of biochemical networks by stochastic di erential equations (SDE) has been successfully used as a basis for statistical inference for such models. Since Monte Carlo based inference can be time consuming for SDEs, we suggest a di erent approximate approach. The idea is that a di usion model applies well to chemical kinetics, when the number of molecules of each type is large. In this limit, also the number fluctuations are small leading to a small di usion term compared to the drift. This suggests the application of a weak noise expansion.

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